[CAS NO. 26833-85-2]  Harringtonine

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PRODUCTS SPECIFICATIONS [26833-85-2]

Store
Catalog
SLK-S9063
Brand
Selleck
CAS
26833-85-2

DESCRIPTION [26833-85-2]

Overview

MDL-
Molecular Weight531.59
Molecular FormulaC28H37NO9
SMILESO(C([C@@](CCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.8811 mL9.4057 mL18.8115 mL
5 mM0.3762 mL1.8811 mL3.7623 mL
10 mM0.1881 mL0.9406 mL1.8811 mL
50 mM0.0376 mL0.1881 mL0.3762 mL

Description

Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.

In vitro

Harringtonine, a cephalotaxine alkaloid, inhibits an early stage of the chikungunya virus (CHIKV) replication cycle which occurs after viral entry into cells and affects CHIKV RNA production as well as viral protein expression, also inhibits other alphaviruses.[1]


Synonyms

Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]
Harringtonine
Cephalotaxine, 4-methyl 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), [3(R)]-
Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)
4H-Cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepine, cephalotaxine deriv.
Harringtonin
2′R-Harringtonine
NSC 124147