[CAS NO. 69884-00-0] Pseudoginsenoside F11

Name: Pseudoginsenoside F11
Brand: Arctom Scientific
SKU: SLK-S9199

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PRODUCTS SPECIFICATIONS [69884-00-0]

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Catalog

SLK-S9199

Brand

Selleck

CAS

69884-00-0

DESCRIPTION [69884-00-0]

Overview

MDL	-
Molecular Weight	801.01
Molecular Formula	C42H72O14
SMILES	C[C@]12[C@@]([C@]3(C)[C@@]([C@@H](O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)C1)(C(C)(C)[C@@H](O)CC3)[H])(C[C@@H](O)[C@]6([C@@]2(C)CC[C@@]6([C@@]7(C)O[C@@H](C(C)(C)O)CC7)[H])[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.2484 mL	6.2421 mL	12.4842 mL
5 mM	0.2497 mL	1.2484 mL	2.4968 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL
50 mM	0.0250 mL	0.1248 mL	0.2497 mL

Description

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial agonist.

Targets

PPARγ ^[1]

In vitro

Pseudoginsenoside F11 (PF11) promotes the differentiation of 3T3-L1 preadipocytes. It promotes adipogenesis by activating PPARγ. PF11 significantly suppresses the release of ROS and proinflammatory mediators induced by LPS in a microglial cell line N9 including NO, PGE2, IL-1β, IL-6 and TNF-α. Moreover, PF11 inhibits interaction and expression of TLR4 and MyD88 in LPS-activated N9 cells, resulting in an inhibition of the TAK1/IKK/NF-κB signaling pathway. PF11 also inhibited the phosphorylation of Akt and MAPKs induced by LPS in N9 cells.

In vivo

In in vivo studies, PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS. PF11 exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. It may exert therapeutic effects for neurodegenerative disease associated with neuroinflammation.

References

[1] Wu G, et al. PPAR Res. 2013, 2013: 701017.
[2] Wang X, et al. Neuropharmacology. 2014, 79:642-56.

Synonyms

β-D-Glucopyranoside, (3β,6α,12β,24R)-20,24-epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-

Dammarane, β-D-glucopyranoside deriv.

(3β,6α,12β,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Pseudoginsenoside F₁₁

Ginsenoside A₁